摘要：Background: Posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) frequently co-occur after traumatic experiences and share neurocognitive disturbances in verbal memory and executive functioning. However, few attempts have been made to systematically assess the role of a comorbid MDD diagnosis in neuropsychological studies in PTSD.Objective: The purpose of the current study is to investigate neurocognitive deficits in PTSD patients with and without MDD. We hypothesized that PTSD patients with comorbid MDD (PTSD+MDD) would have significantly lower performance on measures of verbal memory and executive functioning than PTSD patients without MDD (PTSD-MDD).Method: Participants included in this study were 140 treatment-seeking outpatients who had a diagnosis of PTSD after various single traumatic events and participated in a randomized controlled trial comparing different treatment types. Baseline neuropsychological data were compared between patients with PTSD-MDD (n=84) and patients with PTSDMDD (n=56).Results: The PTSD+MDD patients had more severe verbal memory deficits in learning and retrieving words than patients with PTSD alone. There were no differences between the groups in recall of a coherent paragraph, recognition, shifting of attention, and cognitive interference.Conclusions: The results of this study suggest that a more impaired neurocognitive profile may be associated with the presence of comorbid MDD, with medium-sized group differences for verbal memory but not for executive functioning. From a clinical standpoint, being aware that certain verbal memory functions are more restricted in patients with comorbid PTSD and MDD may be relevant for treatment outcome of traumafocused psychotherapy.Keywords: neuropsychology; cognitive functioning; PTSD; major depressive disorder; comorbidity(Published: 2 May 2013)For the abstract or full text in other languages, please see Supplementary files in the column to the right (under Article Tools)Citation: European Journal of Psychotraumatology 2013, 4: 19979 - http://dx.doi.org/10.3402/ejpt.v4i0.19979This paper is part of the thematic cluster Psychotrauma research in the Netherlands - more papers from this cluster can be found here.
关键词：neuropsychology; cognitive functioning; PTSD; major depressive disorder; comorbidity
