摘要:Data pemeriksaan kalinesterase DKK Brebes menunjukkan bahwa 19,25% petani mengalami keracunan ringan dan 4,08 % mengalami keracunan sedang, dimana istri petani berisiko mengalami keracunan karena keterlibatan mereka dalam kegiatan pertanian. Tujuan penelitian untuk megetahui faktor-faktor yang berhubungan dengan kejadian keracunan pestisida pada istri petani bawang merah di Desa Kedunguter Kecamatan Brebes Kabupaten Brebes. Penelitian ini merupak a n penelitian observasional dengan desain cross sectional. Sampel penelitian sejumlah 37 orang diambil menggunakan metode purposive sampling. Analisis data dengan menggunakan uji Chi-Square. Hasil penelitian menunjukkan istri petani yang mengalami keracunan sebanyak 29 orang (78,4%). Hasil uji statistik menunjukkan ada hubungan antara keikutsertaan istri dalam kegiatan pertanian (p = 0,0 4 2), tingkat risiko paparan (p = 0,002) dengan kejadian keracunan pestisida. Upaya yang perlu dilakukan adalah tetap berhati-hati terhadap paparan pestisida. Perlu dilakukan sosialisasi, pemantauan dan evaluasi terhadap perilaku petani dan istrinya dalam melakukan aktivitas pertanian serta bahaya penggunaan pestisida oleh instansi terkait. Kata kunci : Faktor-faktor yang berhubungan, istri petani, kejadian keracunan Factors Related to the Incidence of Pesticide Poisioning on Farmers W ife in Kedunguter Vil lage, Brebes Regency, The data of cholinesterase test from Brebes Health Departement showed that 19,25% onion farmers get mild intoxication and 4,08% get severe intoxication which farmer's wife is one of the populations who risked for getting intoxication because of their involvement in agricultural activities. This research was to analyze the factors related to the incidence of pesticide poisioning. This research used observational research with cross sectional approach. The samples are 37 people were taken using the purposive sampling. Data was analized with Chi-Square. Examination results showed farmer's wife who get intoxication are 29 people (78,4%). The results showed relationshipbetween the wifeb participation in agricultural activities (p = 0.042), the level of risk exposure (p = 0.002) with the incidence of pesticide poisoning. Efforts need to doing is to remain cautious due to exposure to pesticides. It ’s needed in doing socialiszation, obsentation, and evaluation to the farmers and wife habit in agriculture activity and the dangers af using pesticide by the related. Keywords : Factors related, the farmer ’s wfe, the incidence of poisoning