标题：Hydrophobicity and kinetic inspection of hydroxide ion attack on some chromen-2-one laser dyes in binary aqueous–methanol and aqueous–acetone mixtures: Initial state-transition state analysis
摘要：Abstract In the present study, reactivity base-catalyzed hydrolysis of 7-dimethylamino-4-methyl-2H-chromen-2-one (DMAC) and 7-diethylamino-4-methyl-2H-chromen-2-one (DEAC) in binary aqueous–methanol and aqueous–acetone mixtures was examined at 298K. Kinetic results, rate laws and reaction mechanisms were established. Moreover, the change in the activation energy barrier of the investigated compounds from water to water–methanol and water–acetone mixtures was estimated from the kinetic data. Base-catalyzed hydrolysis of (DMAC) and (DEAC) in aqueous–methanol and aqueous–acetone mixtures follows a rate law with k obs = k 2[OH]. The decrease in the rate constants of (DMAC) and (DEAC) as the proportion of methanol and acetone is due to the destabilization of OH− ion. The solubilities of the studied compounds, DMAC and DEAC in water–methanol and water–acetone mixtures were established and their transfer chemical potentials were calculated. Solvent effect on reactivity trends of the investigated compounds has been analyzed into initial and transition state components by using the transfer chemical potentials of the reactants and the kinetic data of the studied compounds. The decrease in the observed rate constant values (k obs) of the base hydrolysis of DMAC and DEAC with increasing of methanol% or acetone% is dominated by the initial state (IS).
关键词：Chromen-2-ones; Base-catalyzed hydrolysis; Reaction mechanism; Solvent effect; Activation energy barrier; Initial-transition state analysis;
