标题：Synthesis, assessment of substituent effect and antimicrobial activities of (4E)-4-(benzylideneamino)-1,2-dihydro-2,3-dimethyl-1-phenylpyrazol-5-one compounds
期刊名称：Karbala International Journal of Modern Science
印刷版ISSN：2405-609X
电子版ISSN：2405-609X
出版年度：2016
卷号：2
期号：1
页码：56-62
DOI：10.1016/j.kijoms.2016.01.004
语种：English
出版社：Elsevier
摘要：A series of substituted (4E)-4-(benzylideneamino)-1,2-dihydro-2,3-dimethyl-1-phenylpyrazol-5-one compounds has been synthesized from 4-aminoantipyrine and substituted benzaldehydes. Their structures have been confirmed by their physical constants, UV, IR and NMR spectral data. The observed UV absorption maximum λ max (nm), IR frequencies νCN(cm−1), NMR δ(ppm) of C–H & CN chemical shift values have been correlated with Hammett substituent constants and F and R parameters using single and multi-linear regression analyses. From the results of statistical analysis, the effect of substituents on the spectral data has been studied. The antimicrobial activities of all the Schiff bases synthesized have been studied using Bauer–Kirby method. Graphical Display Omitted
关键词：Synthesis;UV, IR and NMR spectra;Correlation analysis;Antimicrobial activities
