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  • 标题:Power estimation for multiple co-primary endpoints: a comparison among conservative solutions
  • 本地全文:下载
  • 作者:Antonio Lucadamo ; Nadia Accoto ; Daniele De Martini
  • 期刊名称:Italian Journal of Public Health
  • 印刷版ISSN:1723-7815
  • 出版年度:2012
  • 卷号:9
  • 期号:4
  • DOI:10.2427/8671
  • 语种:English
  • 出版社:PREX
  • 摘要:The problem of estimating the power of the multivariate Intersection Union test (IUT) is studied. Four classical parametric solutions and a bootstrap non-parametric one, providing statistical lower bounds (i.e. one directional confidence intervals) for the power, are considered. The performances of these techniques in several bivariate IUT settings are compared through a simulation study. All solutions are biased, since their actual coverage probabilities are higher than the nominal one. The bootstrap solution shows the smallest bias, and the variability of its estimates is the lowest. Moreover, the bias of the bootstrap solution reduces faster than those of the other techniques when the pilot sample size, or the correlation, or the rate between the two non-centrality parameters increases. Also, the non-parametric bootstrap solution can be improved by calibration, with a considerable bias reduction.
  • 关键词:Sample size estimation;Conservative approach;Bootstrap solution
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