摘要：About twenty years ago, systems biology was far away from modeling large metabolic networks due to insufficient computational power to go beyond modeling the reaction kinetics of individual enzymes. Today, after the enormous increases in the speed of computation and growth in data storage capabilities, systems biology is approaching its goal to be able to investigate complex biological systems be it individual cells, tissues, organs or even whole organisms. Furthermore, in systems biology, modeling of pathways not only includes single enzyme reaction kinetics but also higher-level controlling processes such as gene regulation and signal transduction making the in-silico reconstruction of such heterogeneous networks significantly more complicated.
