首页    期刊浏览 2024年11月24日 星期日
登录注册

文章基本信息

  • 标题:Prophylaxis against febrile neutropenia with pegfilgrastim in Italy: a budget impact analysis
  • 本地全文:下载
  • 作者:Giovanni Rosti ; Maria Lebboroni ; Ario Cerchiari
  • 期刊名称:Farmeconomia. Health economics and therapeutic pathways
  • 印刷版ISSN:2240-256X
  • 出版年度:2011
  • 卷号:12
  • 期号:3
  • 页码:119-127
  • DOI:10.7175/fe.v12i3.126
  • 语种:English
  • 出版社:SEEd
  • 摘要:Introduction: prophylaxis with granulocyte colony-stimulating factors (G-CSF) is indicated for reduction in the duration of neutropenia and the incidence of febrile neutropenia in patients treated with cytotoxic chemotherapy for malignancy.
Objective: to evaluate the budgetary impact for the Italian NHS.
Design: a decision-analytic model has been developed to analyze the budget impact from the national health care system perspective. Costs include direct healthcare costs to the public payer of G-CSFs as well as their administration costs and costs of FN-related events. The comparison has been done using prophylaxis with G‑CSF (filgrastim for 11 days, pegfilgrastim, lenograstim for 11 days) and antibiotics.
Patients and participants: The population of interest for the analysis were patients with breast cancer in stage II and III and patients with non-Hodgkin’s lymphoma (NHL).
Main outcome measures and results: for all the three patients group (NHL, Breast II and III), and for all the chemotherapy regimens (CHOP 21 and R-CHOP 21 for NHL, AC-T, TAC and TC for Breast stage II and III) the budget impact analyses shows a cost reduction for the Italian NHS, as a result of an increase of the use of pegfilgrastim.
Conclusions: in Italy, a treatment strategy including pegfilgrastim as either primary or secondary prophylaxis provides value for money.
  • 关键词:Pegfilgrastim;Neutropenia febbrile;Budget impact
国家哲学社会科学文献中心版权所有