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  • 标题:Plasma marker based hepatoprotective evaluation of some novel synthesized benzofluorenone analogues: A medicinal chemistry approach
  • 本地全文:下载
  • 作者:Trimurti L. Lambat ; Trimurti L. Lambat ; Sujata S. Deo
  • 期刊名称:Karbala International Journal of Modern Science
  • 印刷版ISSN:2405-609X
  • 电子版ISSN:2405-609X
  • 出版年度:2017
  • 卷号:3
  • 期号:1
  • 页码:39-45
  • DOI:10.1016/j.kijoms.2017.02.002
  • 语种:English
  • 出版社:Elsevier
  • 摘要:Abstract In an extensive search program towards development of new hepatoprotective agents, a series of novel benzofluorenones have been synthesized. These newly synthesized benzofluorenone derivatives exhibited protection against carbon tetrachloride (CCl4)-induced hepatotoxicity. This activity was estimated by levels of biochemical parameters such as aspartate aminotransferase (AST), serum alanine transferase (ALT), serum alkaline phosphatase (SALP) and total proteins (TP) carried out by using regular assay kits. Graphical abstract Display Omitted
  • 关键词:Benzofluorenones;Hepatoprotective activity;Aspartate aminotransferase;Serum alanine transferase;Serum alkaline phosphatase
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