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  • 标题:The Aldous-Shields model revisited with application to cellular ageing
  • 本地全文:下载
  • 作者:Best, Katharina ; Pfaffelhuber, Peter
  • 期刊名称:Electronic Communications in Probability
  • 印刷版ISSN:1083-589X
  • 出版年度:2010
  • 卷号:15
  • 页码:475-488
  • DOI:10.1214/ECP.v15-1581
  • 出版社:Electronic Communications in Probability
  • 摘要:In Aldous and Shields (1988) a model for a rooted, growing random binary tree with edge lengths 1 was presented. For some $c>0$, an external vertex splits at rate $c^{-i}$ (and becomes internal) if its distance from the root (depth) is $i$. We reanalyse the tree profile for $c>1$, i.e. the numbers of external vertices in depth $i=1,2,...$. Our main result are concrete formulas for the expectation and covariance-structure of the profile. In addition, we present the application of the model to cellular ageing. Here, we say that nodes in depth $h+1$ are senescent, i.e. do not split. We obtain a limit result for the proportion of non-senesced vertices for large $h$.
  • 关键词:Random tree; cellular senescence; telomere; Hayflick limit;60K35; 92D20; 60J85; 05C0
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