标题：Synthesis and spectroscopic characterisation of novel bioactive molecule of 3-(2-substituted)-1H-indol-3-yl)-1-(thiophen-2yl)prop-2-en-1-one chalcone derivatives as effective anti-oxidant and anti-microbial agents
期刊名称：Beni-Suef University Journal of Basic and Applied Sciences
印刷版ISSN：2314-8535
电子版ISSN：2314-8543
出版年度：2016
卷号：5
期号：3
页码：236-243
DOI：10.1016/j.bjbas.2016.08.004
语种：English
出版社：Elsevier
摘要：Abstract The chief purpose of this work was to synthesise and find out the anti-oxidant and anti-microbial activities of novel 3-(2-substituted)-1H-indol-3-yl)-1-(thiophen-2yl)prop-2-en-1-one chalcone derivatives. These derivatives were prepared by performing Claisen–Schmidt condensation reaction of 1-(thiophen-2yl)ethanone and 2 substituted 1H-indole-3-carbaldehyde with constant stirring (approximately for 3 hours) in the presence of ethanol and potassium hydroxide. The newly synthesised compounds' anti-oxidant and anti-microbial activities have been identified by using DPPH radical scavenging assay, zone of inhibition and minimum inhibitory concentration. Most of the prepared compounds had shown excellent anti-oxidant and anti-microbial activities as compared to the standard drugs like Ascorbic acid, Ciprofloxacin and Fluconazole. Among the synthesised compounds, compounds 4e, 4h and 4a showed remarkable activity at low concentration. Therefore, these compounds deserve further research.
关键词：Chalcone;Claisen–Schmidt condensation;DPPH assay;Minimum inhibitory concentration (MIC);Zone of inhibition
