摘要:This work presents a linear, constrained, multivariable predictive control strategy, i.e. EPSAC (Extended Prediction Self-Adaptive Control) applied to a train of three distillation columns. The columns are used to obtain the carbon isotope 13C used widely in medicine and specific industries. The oversimplified models of the three columns stem from a real-life plant designed and constructed in the National Institute for Research and Development for Isotopic and Molecular Technologies, in Cluj Napoca, Romania. The simulation results suggest the strategy is applicable to this process.