摘要:The prevalence of obesity and associated health conditions is increasing, which underscores the importance of developing effective strategies to counteract overweight. It is well known that diet and exercise are the two main ways to loose weight. It is not known, however, how exercise training can induce weight loss.To test this, we compared the combined effect of 30days of two different diets and exercise training on weight loss enhancement. The study was carried out on four groups of rats (n=12); the standard diet sedentary group (SS), standard diet with exercise (SE), high-protein diet with exercise (PE) and high-fat diet with exercise (FE). Significant reductions in weight gain and in food intake were observed with training (p <0.001). Body weight was decreased by protein diet (p <0.01) and increased by fat diet (p <0.001). Fat-diet increased both insulin concentrations (p <0.05), glycaemia (p <0.001) and muscle glycogen (p <0.01).Our results demonstrated the positive effect of physical exercise on reducing both food intake and weight gain. We showed, as well, that combined effect of protein diet and exercise training induced the greatest weight loss. Fat diet, on the contrary, disrupts carbohydrate and fat metabolism and promotes overweight.