摘要：Background: Aerobic physical exercise influences several aspects of diabetic pathology, including cardiomyopathy development. The experimentally-induced diabetic rat model has contributed to advances in this line of research. Objective: The aim of the present study was to examine the effects of moderate aerobic physical training on the metabolic, histological and ultra structural aspects of myocardium in experimental diabetic rats. Methods: Wistar rats were divided into 4 groups, sedentary control (SC), trained control (TC), sedentary diabetic (SD) and trained diabetic (TD). Diabetes was induced by Alloxan (35 mg/kg b.w. i.v.). The aerobic training program consisted by swimming 5 days/week, 1 h/day, supporting a load of 2.5 % body weight for 4 weeks. At the end of the training period, the rats were sacrificed and the blood was collected for determinations of serum glucose and free fat acids (FFA). The myocardium was collected for determinations of histological, histochemistry and ultra structural aspects. Results: Diabetes increased glucose and FFA concentrations in blood and induced histological and histoquimical alterations in myocardium. In the other hand, aerobic physical training was able to restore this alterations. Conclusion: In conclusion experimental alloxan-induced diabetes promoted some metabolic, histological and ultra structural alterations in myocardium of rats and moderate aerobic physical training recuperates some of these alterations.
其他摘要：Background: Aerobic physical exercise influences several aspects of diabetic pathology, including cardiomyopathy development. The experimentally-induced diabetic rat model has contributed to advances in this line of research. Objective: The aim of the present study was to examine the effects of moderate aerobic physical training on the metabolic, histological and ultra structural aspects of myocardium in experimental diabetic rats. Methods: Wistar rats were divided into 4 groups, sedentary control (SC), trained control (TC), sedentary diabetic (SD) and trained diabetic (TD). Diabetes was induced by Alloxan (35 mg/kg b.w. i.v.). The aerobic training program consisted by swimming 5 days/week, 1 h/day, supporting a load of 2.5 % body weight for 4 weeks. At the end of the training period, the rats were sacrificed and the blood was collected for determinations of serum glucose and free fat acids (FFA). The myocardium was collected for determinations of histological, histochemistry and ultra structural aspects. Results: Diabetes increased glucose and FFA concentrations in blood and induced histological and histoquimical alterations in myocardium. In the other hand, aerobic physical training was able to restore this alterations. Conclusion: In conclusion experimental alloxan-induced diabetes promoted some metabolic, histological and ultra structural alterations in myocardium of rats and moderate aerobic physical training recuperates some of these alterations.
