期刊名称：Walailak Journal of Science and Technology (WJST)
印刷版ISSN：2228-835X
出版年度：2014
卷号：12
期号：4
DOI：10.14456/471
语种：English
出版社：Institute of Research and Development, Walailak University.
摘要：A series of substituted pyrimidine has been discovered as a new class of potent antioxidant that is 6-(Substituted aldehyde)- 3,4-dihydro-1-(tetrahydro-3,4-dihydroxy-5-hydroxymethyl)furan-2-yl)-4-(4-hydroxyphenyl)pyrimidine-2(1H)-thione derivative (XVII-XXIV) was synthesized from the 6-(Substituted aldehyde) -4-phenylpyrimidine-2(1H)-thione derivative (IX-XVI) through following reaction mechanism Claisen-Schmidt, Cyclization and Satos fusion . The structures of the synthesized compounds were elucidated by I.R., 1H-NMR, elemental analysis and mass spectroscopic techniques. The synthesized compounds were screened for in-vitro antioxidant activity using the DPPH assay, based on the AAI and AAU, using a combination relation between DPPH concentration and absorbance. The antioxidant strength of compounds was compared against ascorbic acid. Among them, compounds XVII, XX, XIX and XXIV exhibited significant antioxidant activity by free radical scavenging (DPPH) method.
