摘要：The effect of methenolone enanthate (ME), one of the anabolic-androgenic steroids (AAS), used as a muscle amplifier and for doping by athletes, on the humerus bone development of adolescent male and female rats has been researched in this study. Three different groups for each male and female rat, including 8 rats of each, (ME, V, C) were formed and a total of 48 rats were used. The subject groups were given 0.5 mg/kg methenolone enanthate (PrimobolanÒ Depot, Bayer) diluted in peanut oil, 0.5 ml; all animals received five intraperitoneal injections weekly for four weeks. The rats were euthanized at the end of the four weeks and both humerus dissected and macerated. The length, corpus thickness, compact bone thickness and medulla canal diameter were measured with calipers and the average of each was noted. The effect of ME administration on humerus length and corpus femoris thickness was negative in male animals but positive in females and was determined to be statistically significant (p<0.05) in both cases. There was no treatment-related difference in compact bone thickness and medulla diameter (p>0.05), while a significant difference (p<0.05) had been seen between the sexes in medulla diameter in the control groups. Humerus compact bone density in male rats and medulla canal diameter of female rats are significant in terms of the difference between groups (p<0.05), and gender effect on the change arising in medulla canal diameter as a result of ME administration has been revealed to be insignificant (p>0.05). It was concluded that the ME effect on rat humerus, similar to that of other AAS, consists in supressing bone growth in male animals while enhancing it in females during puberty. Rat models show negative middle-term and long-term effects of this agent, which is still widely in use as a performance enhancer, as opposed to its positive results in the short term.
