摘要：AbstractOptimal and safe control of drug delivery systems with continuous infusion protocol is of key importance to avoid over- or under-dosing of the patient. By implementing close-loops one is able to optimize the amount of drug given to the patient. In this paper a robust control methodology is presented. Emerging tools from fractional calculus have been considered and a fractional order PI controller for drug dosing during hypnosis has been designed. In this paper a robust fractional order control of hypnosis is proposed. The controller has been evaluated on an artificial data set of 24 patients and the results indicate that such a control strategy is robust to uncertainty stemming from the inter- and intra-patient variability.
