期刊名称：Beni-Suef University Journal of Basic and Applied Sciences
印刷版ISSN：2314-8535
电子版ISSN：2314-8543
出版年度：2017
卷号：6
期号：4
页码：394-408
DOI：10.1016/j.bjbas.2017.04.013
语种：English
出版社：Elsevier
摘要：AbstractThis study was designed to evaluate the effect ofUlva lactucahydroethanolic extract on rheumatoid arthritis in male Wistar rats. Rheumatoid arthritis was induced in rats by subcutaneous injection of 200µl Freund’s complete adjuvant into a footpad of the right hind leg of male rats at two consecutive days. Arthritic rats were orally treated withUlva lactucahydroethanolic extract at dose level of 100mg/kg b.wt /day for 1, 2 and 3weeks and were compared with corresponding arthritic control at the same periods. The increased right hind paw circumference at tarsal pad, deleteriously affected ankle joint histological architecture, articular inflammatory cell infiltration and focal necrosis in arthritic rats were counteracted by hydroethanolic extract treatment at the three tested periods. Elevated leukocytes count in arthritic rats connected with changes of spleen and thymus histological architecture, extramedullary megakaryocytes, lymphoblasts activation and mitotic figures were significantly improved byUlva lactucahydroethanolic extract treatment at the three tested peroids. The elevated rheumatoid factor (RF), prostaglandin E2(PGE2), tumor necrosis factor-alpha (TNF-α), interleukin-17 (IL-17) and interleukin-1beta (IL-1β) levels and the lowered interleukin-4 (IL-4) level in arthritic rats were markedly ameliorated as a result ofUlva lactucaadministration. The lowered glutathione level and glutathione peroxidase, glutathione reductase and superoxide dismutase activities as well as the elevated lipid peroxides level in serum of arthritic rats were potentially alleviated as a result ofUlva lactucatreatment. In conclusion,Ulva lactucacould have anti-arthritic efficacies which may be mediatedviaits anti-inflammatory and anti-oxidant potentials.
