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  • 标题:An α2,3-Linked Sialylglycopolymer as a Multivalent Glycoligand Against Avian and Human Influenza Viruses
  • 本地全文:下载
  • 作者:Tomonari Tanaka ; Yiting Zhou ; Chihiro Tamoto
  • 期刊名称:Journal of Applied Glycoscience
  • 印刷版ISSN:1344-7882
  • 电子版ISSN:1880-7291
  • 出版年度:2017
  • 卷号:64
  • 期号:2
  • 页码:43-48
  • DOI:10.5458/jag.jag.JAG-2017_003
  • 语种:English
  • 出版社:The Japanese Society of Applied Glycoscience
  • 摘要:A glycopolymer bearing α2,3-linked sialyltrisaccharides was synthesized by living radical polymerization using a glycomonomer prepared by a protecting-group-free process, direct azidation of the free sialyllactose, and subsequent azide-alkyne cycloaddition. The prepared glycopolymer with pendant 3´-sialyllactose moieties strongly interacted with both avian and human influenza viruses analyzed by the hemagglutination inhibition assay and the quartz crystal microbalance method.
  • 关键词:sialyloligosaccharide;protecting-group-free;click chemistry;RAFT polymerization;glycocluster effect;influenza virus
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