期刊名称：Journal of Environmental & Analytical Toxicology
电子版ISSN：2161-0525
出版年度：2014
卷号：4
期号：6
DOI：10.4172/2161-0525.1000238
语种：English
出版社：OMICS International
摘要：Our study was aimed to evaluate the effects of cadmium on chick embryo liver tissue. 10th, 11th and 12th day old Bobcock strain chick embryos were exposed to cadmium individually, by in ovo treatment. These concentrations 40, 50, 60 μg of Cadmium at different time intervals i.e., 24, 48, 72 hr, were administered to developing chick embryo. On the 13th study day, blood and the liver tissues collected were tested for genotoxic and lipid peroxidation assays. In this study, the presence of micronucleated erythrocytes and also various abnormal cells in the blood smear indicated the role of cadmium-induced genotoxicity. Current findings showed that frequency of micronucleated erythrocytes increased with increased doses of cadmium and time interval. MDA levels were high in cadmium exposed group compared to control group. These findings suggest the genotoxic and an oxidative stress mechanism in cadmium-induced liver tissue enhances damage.
关键词：Cadmium; Chick embryo liver; Lipid peroxidation assay;
Genotoxicity; Micronucleus test; in ovo injection; Oxidative stress
