摘要:Hospital Information Systems (HIS) has been widely used in Indonesia. This implementation in hospital needs comprehensive, integrated information system designed to manage all the aspects of a hospital's operation. One of the factors that currently plays an important role in the successful HIS’s application is the user factor. The hospital can evaluate HIS from user factor, so that it becoming better, perfect and can support the objectives, vision and mission of the hospital. This study aims to use the Modified Technology Acceptance Model created in Structural Equation Modeling (SEM) and tested using the software Amos 20 to determine the variables that most influence in HIS’s application using in several hospitals in Sleman, Daerah Istimewa Yogyakarta Province, Indonesia. Data collected by distributing questionnaires to employees of D grade hospitals in Sleman district. The results from this study are seven variables that may influence the user in using HIS (Subjective Norm, Perceived Usefulness, Perceived Ease of Use, User Satisfaction, Behavior Intention to Use, Attitude Toward Using, Actual System Usage) and significant or insignificant relationship among them.