期刊名称：Journal of Environmental & Analytical Toxicology
电子版ISSN：2161-0525
出版年度：2012
卷号：2
期号：2
DOI：10.4172/2161-0525.1000123
语种：English
出版社：OMICS International
摘要：This investigation examined the reproductive toxic effects and oxidative stress of sodium fluoride (NaF) in male albino rats (Rattus norvegicus). The rats received acute doses of NaF as 0.5 ppm, 200 ppm and 500 ppm through drinking water for 15 days. Additionally 10 mg ascorbate was also supplemented after NaF treatment as an antidote. The dose 0.5 ppm was ineffective and 500 ppm was fatal after 4 days onwards. A significant decrease in ascorbate content of liver and increase in cholesterol content of liver and testes after 200 ppm NaF-15 days treatment was examined but their level from adrenals did not change significantly. Histological studies of testes in these animals indicated atrophy of steroidogenic cells. Almost similar results were obtained when ascorbate was supplemented as an antidote.
