摘要:A project to customize pre-acclimatization programs based on individual susceptibility to hypoxia was planned for the 2010 FIFA World Cup. To assist this project, we analyzed physiological responses and evaluated susceptibility to hypoxia. Thirty-eight Japanese national soccer team members performed the hypoxic ventilatory response (HVR) test and running test. The running protocol was set at 150 m•min~(-1) (Run150) and 250 m•min~(-1) for 3 min (Run250) under normoxia and hypoxia (simulating 2000 m). Blood lactate concentrations (La), heart rate (HR), and oxygen saturation levels (SpO_2) were monitored during the running test. The rates of change in these parameters were calculated by comparison between hypoxia and normoxia at each speed. To identify players who were severely affected by hypoxia, they were ranked using a point system based on the order of HVR and the rates of change. Large individual differences in HVR (0.000-1.520 L•min~(-1) •% ~(-1) ) and rates of change in La (e.g., -11.1 to 73.7% at Run250), HR (-3.4 to 16.0%, similarly), and SpO_2 (-5.5 to -16.5%, similarly) were found. Our data suggest that understanding and assessing individual susceptibility to hypoxia is important for altitude preparation.