摘要：Evidence shows that physical exercise carried out systematically promotes numerous health benefits, including improvements in glucose homeostasis. Of all types of physical activity, resistance training is effective in promoting increased strength, speed, power, hypertrophy, and metabolic effects such as increased insulin sensitivity and control in glycogen metabolism. Since there are still gaps requiring attention in regards to the molecular mechanisms leading to effective insulin signaling, this paper attempts to review the effects and implications of resistance exercise on the major intracellular protein activities. In this regard, we set out to understand the role of resistance training on IRS1, IRS2, PI3K, Akt/PKB, and GLUT4 activity, which can lead to the development of possible future interventions to improve physical performance and mitigate the effects of altered metabolic conditions such as obesity, insulin resistance, and type 2 diabetes mellitus.
