期刊名称：ePlasty: Open Access Journal of Plastic and Reconstructive Surgery
印刷版ISSN：1937-5719
出版年度：2018
卷号：18
语种：English
出版社：Open Science Co. LLC
摘要：Introduction:New treatments that promote wound healing while preventing scar formation are needed. One option in topical wound healing is the use of temporary dressings that allow the natural healing process with minimal scar formation.Methods:We evaluated the temporary wound dressings PermeaDerm C, and a PermeaDerm C derivative coated with the anti-scarring agent, salinomycin (PermeaDerm D) in a pig model of wound healing to show the efficacy of these wound dressings in vivo.Results:Porcine fibroblasts grow well in the presence of PermeaDerm C or PermeaDerm A, and salinomycin reduces excessive myofibroblast formation in porcine fibroblasts in vitro. In vivo, wounds treated with PermeaDerm C and PermeaDerm A did not show abnormal or unwanted healing patterns up to 8 weeks post–wound formation. Wounds covered with either PermeaDerm C or PermeaDerm A showed a more mature wound-healing phenotype than the control wounds.Conclusions:PermeaDerm C and PermeaDerm A allowed wound healing, revealing the potential of both PermeaDerm C and PermeaDerm A to promote effective healing while preventing excessive scar formation.
