摘要：During the recent years, scientific studies are concentrated upon the possible oxidative stress which is caused by the exhaustive stress. Caffeic acid phenethyl ester (CAPE) is a significant active constituent of propolis, which is originated from honeybee hives. Thanks to its antioxidant, antiproliferative, antiinflammatory, antiviral and antifungal activities, it has received growing attention in several medical and pharmaceutical researches. The purpose of this study was to examine the impacts of CAPE in exercise-induced oxidative stress. Sprague-Dawley Rats (250-300 g) were separated into four groups in this study. The samples of blood and tissues were collected for the examination of biochemical markers and comet assay. Acute swimming exercise led to DNA damage in mononuclear leukocytes and enhanced 8-OhdG levels and also, CAPE significantly (p<0.05) reduced the MDA and 8-OhdG levels. According to findings, it is pointed out that CAPE supplementation reduced DNA damage and enhanced of oxidative stress owing to exhaustive exercise.
