摘要：The aim of this study is to determine the changes occurring in serum paraoxonase (PON) activity, high density lipoprotein (HDL), total antioxidant / oxidant status (TAS/TOS), nitric oxide (NO), and whole blood glutathione (GSH) levels in sheep with Babesiosis (pre-treatment and posttreatment) compared to healthy sheep. 24 adult awassi sheep with Babesiosis (pre-treatment and post- treatment) that had a weight of 25-35 kg, were 3-5 years old, and were clinically suspicious (body temperature of 39-42°C, icterus, anemia, hematuria) as well as 20 healthy adult awassi sheep were used in the study. PON activity, HDL, TAS/TOS, NO, and whole blood GSH levels were measured in complete blood and serum samples obtained from blood samples taken from animals. Compared to healthy sheep, PON activity, TAS, HDL, and whole blood GSH levels of sheep naturally infected with Babesia ovis decreased, their TOS and NO levels increased. After the treatment, biochemical parameters of sheep with Babesiosis were determined to become closer to values of healthy sheep. Cholangiohepatitis, hyperemia in central and portal vein, lymphohistiocytic, areas of focal necrosis, and leukocyte cell infiltration in perivascular/parenchymal areas were observed in histopathological examination of liver cross sections from animals with Babesiosis. Consequently, it was determined that in sheep with Babesiosis parasites caused a shift in oxidant/antioxidant balance of host organism in favor of oxidants and this caused negative conditions to occur in development of animal by creating oxidative stress.
