摘要：Hesperidin is a compound found primarily in citrus fruits, which provides the body with flavanone glycoside. Recent studies have revealed its antiinflammatory, neuroprotective and antioxidant effects. The aim of this study was to to determine the possible effects of hesperidin on liver damage in experimental obstructive jaundice (OJ). For experiments, equally distributed eight groups were formed with 32 Wistar-Albino female rats and the following supplementation were given to each group: Group 1- Sham-operated group, Group 2-Sham + Hesperidin (150 mg/kg/day), Group 3- Bile duct ligation (BDL), Group 4-BDL + Hesperidin (150 mg/kg/day). After the supplementation, a significant increase was observed in serum levels of aspartate aminotransferase (AST), and alanine aminotransferase (ALT) activities, and the levels of Direct Bilirubin (D. Bilirubin), Indirect Bilirubin (ID. Bilirubin) and hepatic lipid peroxidation (LPO) and glutathione (GSH) were determined. In addition, a significant increase was observed in serum levels of AST, ALT, TG, D. and ID. Bilirubin, hepatic LPO levels of Group 3 compared to Group 1. The serum levels of AST, ALT, TG and hepatic LPO levels Group 4 were notably lower than that of Group 3. It was concluded that hesperidin may be effective on experimental obstructive jaundice, therefore, can be used in treatment of OJ.
