摘要：This study aimed to evaluate the toxicity of stonefish venom isolated from genus Synanceia verrucosa, collected during winter 2015 and spring 2016 along the Jordanian coastline of Gulf of Aqaba, Red sea. Stonefish venom was isolated from the venom glands of the dorsal spines. Venom was intramuscular injected in experimental animal BALB c/mice in order to evaluate the adverse effect of the venom on mice lung tissues by studying histological changes and the biochemical effect on the Alanine Aminotransferase (ALT) enzymatic activity. Results showed that the median lethal dose of the extracted venom was 0.107mg venom/kg mice body weight. Histological results showed pathological developments among the selected tissues. Lunge showed deformation in overall structure, severe inflammation, hemorrhage and cellular degeneration. Moreover, significant increasing in the enzymatic activities of Alanine transaminase (ALT) was found as a result of cellular injuries caused by the stonefish venom. The observed pathological changes reflect the possibilities of failure in the respiratory system functions with time as a result to stonefish venom.
