摘要：Ring-Dimiriou S, Kedenko L, Kedenko I, Feichtinger RG, Steinbacher P, Stoiber W, Foerster H, Felder T, Mueller E, Kofler B, Paulweber B. Does Genetic Variation in PPARGC1A Affect Exercise-Induced Changes in Ventilatory Thresholds and Metabolic Syndrome? JEPonline 2014;17(2):1-18. It has been demonstrated that single nucleotide polymorphism (SNP) in the peroxisome proliferator-activated receptor-γ coactivator-1α gene (PPARGC1A, rs8192678, G/A) affect the exercise-induced change in maximal oxygen uptake (VO2). However, studies investigating the effect of this SNP on submaximal exercise performance markers are quite sparse. Therefore, we investigated the effect of a 10-wk supervised cycling training (3x 60 min·wk-1 ) on VO2 and work rate at the point of optimal ventilatory efficiency (POE), anaerobic threshold (ANT), respiratory compensation point (RCP), and maximum level in subjects withdifferent genotypes in PPARGC1A. Analyses were completed in 24 untrained men aged 58 ± 6 yrs.Regarding genotype (G/A; Gly482Ser), three groups were formed (3x n=8): GT1 (G/G, wild type,common allele frequency); GT2 (A/A, homozygous); and GT3 (G/A, heterozygous). Before and afterthe exercise intervention blood samples and body composition in the fasted state were tested, and anincremental cycle ergometer test (10 W·min-1) until volitional exhaustion with measurements ofrespiratory gas exchange and heart rate were completed. In sum, the occurrence rate of metabolicsyndrome was not affected by genotype or short-term supervised cycling. Ten weeks of cycling at 80-100% ANT and 90-120% RCP improved VO2 and work rate at POE and RCP significantly.Furthermore, repeated ANOVA revealed a significant interaction between genotype and exercise withthe highest responder in GT1 compared to GT3 and GT2. The results of this prospective study pointtowards the hypothesis that the SNP rs8192678 affects the trainability of aerobic capacity measuredas VO2 or work rate at RCP of previously untrained middle-aged men.
