摘要：Williams, JS, Ferris, LT. Effects of Endurance Exercise Training on Brain-Derived Neurotrophic Factor. JEPonline 2012;15(4):11-17. As a member of the growth factor family, brain-derived neurotrophic factor (BDNF) has been identified as an important mediator of neuronal health. The purpose of this investigation was to determine the effects of an endurance training program on basal levels of BDNF. Eighteen physically active subjects completed a 12-wk supervised jogging class (3x/wk, 30 min/session, 65-70% HR max). A graded exercise test was conducted before and after the training program to determine maximal oxygen consumption (VO2 max) and maximal work rate (WR max) on a cycle ergometer. Blood samples for basal serum BDNF and cortisol (COR) were also obtained before, at the mid-point, and after the training program. Training resulted in a significant increase (P<0.05) in VO2 max and WR max. Both BDNF and COR were unchanged (P>0.05) in response to the training program. It was concluded that aerobic exercise training of this intensity, frequency, and duration did not provide an adequate training stimulus to result in a significant upregulation of basal BDNF.
