摘要：Morozov VI, Kalinski MI, Sakuta GA, Carnes AJ. Fatty Acid-Binding Proteins (FABPs) as Markers of Myocardium and Skeletal Muscle Injury: A Review. JEPonline 2013;16(5):77-89. The characteristics, properties, and functions of fatty acid-binding proteins (FABPs) are reviewed. FABPs are small cytoplasmic proteins with molecular mass 15 kDa and broad ligand specificity. The long-chain fatty acids (LCFA) are important FABP ligands with great importance in the energy metabolism of the cell. Heart-type (H-FABP) works in myocardium and skeletal muscle, providing fatty acid transport to the working muscles. The acute myocardial infarction (AMI) results in elevated HFABP blood concentration, which may have diagnostic use in patients with cardiac events and in cardiac intervention. This marker may also have predictive value for the assessment of AMI consequences. Exercise results in the release of muscle H-FABP into the blood and its measurement may be useful for assessing exercise-induced skeletal muscle injury. Determination of myoglobin concentration and calculation of the myoglobin/H-FABP ratio may help to differentiate between myocardium and skeletal muscle injury. Endurance training is accompanied by elevation of LCFA transporters in the myocyte membrane, providing enhanced capacity for myocyte fatty acid uptake. Methods of H-FABP analysis are also discussed.
