期刊名称：Beni-Suef University Journal of Basic and Applied Sciences
印刷版ISSN：2314-8535
电子版ISSN：2314-8543
出版年度：2018
卷号：7
期号：1
页码：50-54
DOI：10.1016/j.bjbas.2017.06.003
语种：English
出版社：Elsevier
摘要：Highlights•The study evaluated the antileishmanial activity of four medicinal plants collected from the North-West of Morocco.•Medicinal plant extracts are rich in phenolic contents such as polyphenol and flavonoids.•n-Hexane extracts ofArbutus unedoandCistus crispusshowed remarkable antileishmanial activities.•Leishmania infantumwas the most sensitive strain toward tested parasites.AbstractThe aim of this study is to evaluate the antileishmanial activity of selected medicinal plants from the North-West of Morocco. Plant extracts were prepared by maceration using methanol, ethanol, and n-hexane.The antileishmanial activity was evaluated againstLeishmania major, Leishmania tropica,andLeishmania infantumusing MTT (3-(4.5-dimethylthiazol-2yl)-2.5-diphenyltetrazolium bromide) assay. All plant extracts showed a reducing in cell promastigotes viability with variability depending on tested strains and type of extracts. The n-hexane extract showed the highest antileishmanial activity andL. infantumwas the most sensitive parasite. The best growth inhibition was observed withCistus crispusn-hexane extract againstL. major(IC50=47.29±2.25μg/mL),Arbutus unedon-hexane extract againstL. infantum(IC50=64.05±1.44μg/mL) andArbutus unedon-hexane extract againstL. tropica(IC50=79.57±2.66μg/mL). Considering these results, medicinal plants from the North-West of Morocco could constitute a promoter source for antileishmanial compounds.
