期刊名称：Beni-Suef University Journal of Basic and Applied Sciences
印刷版ISSN：2314-8535
电子版ISSN：2314-8543
出版年度：2018
卷号：7
期号：2
页码：231-234
DOI：10.1016/j.bjbas.2018.02.003
语种：English
出版社：Elsevier
摘要：Highlights•Pomegranate peels aqueous extract is lethal forAscaridia galli in vitroandin vivo.•Pumpkin seeds ethanolic extract showed a lethal effect againstAscaridia galli in vitroandin vivo.•Pumpkin seeds ethanolic extract was more effective than pomegranate peels aqueous extractin vivo.AbstractPumpkin seeds (Cucurbita pepo) and Pomegranate peel (Punica granatum) have anthelmintic properties. The aim of this study was to compare the anthelmintic efficacy of pumpkin seeds ethanolic extract and pomegranate peel aqueous extract againstAscaridia galli in vitroandin vivoin Baladi chicks. On adult worms, the extracts of the two herbs were comparedin vitroat concentrations of 25, 50, and 75 mg/ml with fenbendazole at a concentration of 5 mg/ml. Chicks were infected withAscaridia gallieggs containing second stage larva and treated with 2000 mg/kg of each of the extracts compared with 100 mg/kg fenbendazole.In vitro, all concentrations of pumpkin seed extract and the concentration of 75 mg/ml pomegranate peel extract exhibited a nearly similar effect to fenbendazole.In vivo, the mortality rate of the worms extracted from the 2000 mg/kg pumpkin seeds extract-treated chicken was non-significantly different from that of fenbendazole for 48 h. While pomegranate peels extract exhibited a lower lethal effect than fenbendazole. The anthelmintic efficacy was dependent on time and concentration. The study presented the anthelmintic efficacy of the pumpkin seeds and pomegranate peel extracts onAscaridia galli.Pumpkin seed extract was more effective than pomegranate peel extract. Future studies to determine the optimal dose to maximize their effectiveness especially for pumpkin seeds as anthelmintic therapeutic are required.
关键词：Pomegranate peel;Pumpkin seeds;Anthelmintic;Ascaridia galli;In vitro;In vivo
