摘要：Dynamic axial compression (DAC) columns are key elements in simulated moving bed, which is a chromatography process in drug industry and chemical engineering. In this study, rules for designing distributors are proposed based on mass conservation and validated by experiments, the computer aided design (CAD) and the computational fluid dynamics (CFD). Experimental works are conducted to choose feasible numerical parameters for simulations. In CFD, the transient laminar flow fields are governed by the momentum and species transport equations with Darcy's law to model the porous zone in the packed bed. Results show that CFD combined with CAD solid modelling is a good approach to explore detailed flow fields in DAC columns and carry out parameter analysis for innovative designs. For further testing and evaluation, a new model of compound distributor is designed, 3D printed and processed in factory for practical applications in preparative chromatography.
