摘要：Although the atrophy patterns associated with Primary Progressive Aphasia (PPA) have been described, because of the anatomic variability within the population, the structural imaging has not always been usefiil to diagnose individual cases(Wilson et al.，2009). A quantitative image analysis could allow the objective assessment of the atrophy, assisting the diagnosis and classifications. Quantitative analyses, however, are largely dependent on the accuracy of the image normalization, which is a significant issue for PPA subjects that exhibit a large and variable degree of brain atrophy.
