摘要：The neurobiological mechanisms underlying aphasia recovery remain largely unknown. Although, it is widely accepted that reactivation of pre-morbid language circuits may result in the best recovery, most research has focused on describing the role of brain areas, and little is known about changes in exchange of information (Functional connectivity —FC) between areas and circuits that sustain aphasia reœvery. The present MRI study describes the impact of language therapy on FC circuits that characterize normal word learning. Specifically, the degree of integration between and within neural circuits is described in a group of participants with chronic aphasia, who improved from severe anomia following with Semantic Feature Analysis. This approach provides a data-driven perspective of therapy-induced brain plasticity in aphasia recovery.
