摘要：Two critical issues in aphasia treatment concern the neural underpinnings of recovery, and the time limits of therapeutic benefits. As to the first, most neuroimaging studies document activations in perilesional areas, and in contralesional homologues of damaged language areas. Several studies stress that only perilesional activation correlates with functional recovery, and that right-hemisphere activation may be maladaptive. As to the second, reports on very chronic subjects are very rare. Therefore, it is still unclear for how long post-onset language treatment can be behaviorally and neuro functionally effective. We investigated these issues in subject PPE, who had become aphasie 27 years earlier, following extensive left frontotemporoparietal damage.
