摘要：AbstractProphet Muhammad (SWS) once stated that habbatus sauda (black seed) can heal every disease except death. To our knowledge the effect of this seed on autoimmunity process has never been examined.This study was carried out in UiTM Malaysia to investigate the potential immunomodulatory effect of administration of the major component of Habbatus Sauda; (Thymoquinone) in the autoimmune disease process of type 1 diabetes mellitus as a common example of autoimmune diseases. We have evaluated with the help of ELISA kits the levels of anti- islet cell autoantibodies (ICA), Pan T lymphocytes marker, Pan B lymphocytes marker, and Pan innate cells marker in male Sprague-Dawley rats with Streptozocin-induced the autoimmune disease process of type 1 diabetes mellitus. The four groups (6 rats each) under study received or not different doses of Thymoquinone. The results have been compared to the ones obtained from healthy and non treated diabetic rats. The administration of Thymoquinone especially in high doses to the type1 diabetic rats leads to a significant decreases in the levels of all immunological parameters and stop the disease process (p<0.001). The data may provide new strategies about Habbatus Sauda to be recommended in the clinical management of autoimmune diseases as one of documented halal prescription.
