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  • 标题:On stability analysis of genetic regulatory networks represented by delay-differential equations ★
  • 本地全文:下载
  • 作者:Laurie Haustenne ; Georges Bastin ; Jean-Michel Coron
  • 期刊名称:IFAC PapersOnLine
  • 印刷版ISSN:2405-8963
  • 出版年度:2015
  • 卷号:48
  • 期号:1
  • 页码:453-457
  • DOI:10.1016/j.ifacol.2015.05.108
  • 语种:English
  • 出版社:Elsevier
  • 摘要:AbstractThe purpose of this note is to give a short presentation of a general method for the stability analysis of the steady-states of genetic regulatory networks represented by delay- differential equations. Two complementary ways are investigated: a frequency domain approach which applies to linearized models and gives necessary and sufficient conditions for the local steady-state stability, a Lyapunov approach derived from the viewpoint of hyperbolic PDE systems which gives sufficient conditions for global stability. These methods are illustrated with the example of the “toggle switch”.
  • 关键词:KeywordsGenetic regulatory networkHyperbolic systemLyapunov functionStability
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