期刊名称：Karbala International Journal of Modern Science
印刷版ISSN：2405-609X
电子版ISSN：2405-609X
出版年度：2018
卷号：4
期号：1
页码：86-92
DOI：10.1016/j.kijoms.2017.11.002
语种：English
出版社：Elsevier
摘要：AbstractSilver nanoparticles have gained considerable importance in recent years due to their diverse medicinal activities. In the present study, we have explored filamentous fungiPenicillium italicumfor the extracellular biosynthesis of silver nanoparticles (AgNPs) and evaluated its antibacterial and anticancer effects. The nanoparticles were characterized by using UV–Visible and Fourier transform infra-red (FTIR) spectroscopy and transmission electron microscopy (TEM) analysis. UV–Visible spectra showed specific absorption peak at 422.67 nm which confirmed the presence of nanoparticles. FTIR spectroscopy analysis revealed the presence of alcohols, phenols, alkenes, and amines that play major roles in stabilizing the synthesized AgNPs. Transmission electron microscopy (TEM) analysis showed spherical shape of AgNPs with size ranges from 14.5 nm to 23.3 nm. Antibacterial studies againstStaphylococcus aureus,Salmonella enterica,Bacillus cereus, andEscherichia colithrough disc diffusion method revealed 20 mm (for 40 μg/ml) of inhibition of zone especially forS. entericaand exhibited excellent synergistic effect when combined with moxifloxacin and streptomycin. Further, in anticancer studies, these nanoparticles demonstrated good anticancer effect against HEp-2 cancer cell line with IC50 value at 30 μg/ml through MTT assay.
