摘要：Diversified actinomycete species were isolated from coal fields of Andhra Pradesh and dominantgenera were separated. A total of eleven antibiotic microbial producers have been isolated fromthe coal soil, five of them have shown activity against both Gram-positive and Gram-negativebacteria. On the other hand, six isolates were only active against Gram-positive bacteria. Theyexhibited resistance to ampicillin, tetracycline, rifampicin, methicillin, streptomycin,streptothricin and chlorotetracycline and taken HIV-drugs like Lamostad-N-30, Trimune-30,zidovudine contain L = Laminarin, S = Stavudine and n = nevirapine but slight resistance factoridentified by HIV-drugs against mandamarri strain of coal site of Andhra Pradesh. Metabolitesproduced by the strain showed good antimicrobial activity against Gram-positive and Gramnegativebacteria.
