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  • 标题:Fluorometric Investigation on the Interaction of 5-Bromo and 5- Iodouracil with Bovine Serum Albumin
  • 本地全文:下载
  • 作者:S. Bakkialakshmi ; D. Chandrakala
  • 期刊名称:Archives of Applied Science Research
  • 印刷版ISSN:0975-508X
  • 出版年度:2011
  • 卷号:3
  • 期号:2
  • 页码:174-179
  • 语种:English
  • 出版社:Scholars Research Library
  • 摘要:The Interaction of 5-Bromouracil (5BU) and 5-Iodouracil (5IU) with bovine serum albumin(BSA) were studied by spectroscopic method. Quenching of fluorescence of serum albumin bythese drugs was found to be a static quenching process. Based on the interaction studies carriedout the number of binding sites for drug on protein have been evaluated. The binding constant(Ka) were 2.013 x 104 and 4.062 x 104 L mol-1 for 5BU and 5IU.
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