首页    期刊浏览 2024年09月20日 星期五
登录注册

文章基本信息

  • 标题:Antimicrobial peptides from echinoderms as antibiofilm agents: a natural strategy to combat bacterial infections
  • 本地全文:下载
  • 作者:D. Schillaci ; M. G. Cusimano ; D. Russo
  • 期刊名称:The European Zoological Journal
  • 电子版ISSN:2475-0263
  • 出版年度:2014
  • 卷号:81
  • 期号:3
  • 页码:312-321
  • DOI:10.1080/11250003.2014.922128
  • 语种:English
  • 出版社:Taylor & Francis Group
  • 摘要:Increased attention has been focused on marine invertebrates as a source of bioactive molecules for biomedical applications. Many bioactive molecules are part of the innate immune system. Some more recently isolated compounds, mainly from the sea urchin and the sea cucumber, are antimicrobial peptides (AMPs) active against Gram-positive and Gram-negative bacteria, and fungi. In this review we described the most recent studies on AMPs isolated from echinoderms. AMPs are small peptides (< 10 kDa) with cationic charge and amphipathic structure. Recently, it was demonstrated that in the coelomocyte lysates of Paracentrotus lividus and Holothuria tubulosa, AMPs possess activity against staphylococcal and Pseudomonas aeruginosa biofilms. The data shows a great potential for application of AMPs in biotechnology for developing novel therapeutic agents that are either alternative or complementary to conventional antibiotic therapy to combat multi-resistant pathogens.
  • 关键词:Antimicrobial peptides; echinoderm; Paracentrotus lividus; Holothuria tubulosa; antibiofilm
国家哲学社会科学文献中心版权所有