摘要：Chronic renal failure (CRF) is an independent risk factor for all cause-mortality in general population. Renal failure has become one of the major challenges, resulting in a serious public health issue and economical burden. Kidneys filter fluids and waste materials and can reabsorb or secrete nutritional elements. Calcium-sensing receptor (CaSR) protein is located in renal cells. Increased calcium binding to CaSR prevents reabsorption of calcium from filtered fluids. The CaSR is a typical G protein-coupled receptor. Single nucleotide polymorphism (SNP) of Rs17251221 is found in an intron of CaSR gene.
