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  • 标题:Synthesis and antimicrobial evaluation of certain purine, benzothiazole and thiazole systems substituted with dialkylaminoalkyl- o-cresols
  • 本地全文:下载
  • 作者:Khaled R.A. Abdellatif ; Khaled R.A. Abdellatif ; Ghada A. Abd El Wareth
  • 期刊名称:Beni-Suef University Journal of Basic and Applied Sciences
  • 印刷版ISSN:2314-8535
  • 电子版ISSN:2314-8543
  • 出版年度:2015
  • 卷号:4
  • 期号:1
  • 页码:52-59
  • DOI:10.1016/j.bjbas.2015.02.008
  • 语种:English
  • 出版社:Elsevier
  • 摘要:AbstractNovel series of dialkylaminoalkyl-o-cresols incorporated with purine nucleus2a–b, benzothiazole nucleus5a–b,8a–band thiazole nucleus11a–d,13a–dwere synthesized through Mannich reaction. Structures of the newly synthesized compounds have been deduced on the basis of elemental analysis and spectral data. Antimicrobial activity evaluation was carried out for all synthesized compounds; most of them exerted comparable activity to ciprofloxacin and flucanazole. The thiazole derivatives11a,13c,13dare the most potent compounds.
  • 关键词:Purine;Benzothiazole;Thiazole;o;-cresols;Antimicrobial activity
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