标题：Study of antimicrobial, analgesic wound healing and antioxidant activities of some newly synthesized oxychinolin derivatives and their characterization
期刊名称：Beni-Suef University Journal of Basic and Applied Sciences
印刷版ISSN：2314-8535
电子版ISSN：2314-8543
出版年度：2015
卷号：4
期号：3
页码：232-245
DOI：10.1016/j.bjbas.2015.08.001
语种：English
出版社：Elsevier
摘要：AbstractA series of aryl and heteroaryl substituted oxychinolin derivatives have been synthesized and spectral characterizations have been conducted with different modern analytical techniques. The antimicrobial activities of the novel synthesized oxychinolin analogs against different microbial strains have been screened by agar diffusion method. The compounds4gand4hwere observed with significant antibacterial activity in comparison to reference antibiotic (ampicillin) against most of the bacterial pathogens. Compounds 4-((8-hydroxyquinolin-5-yl) diazenyl)-N-(5-methyl isoxazol-3-yl) benzene sulfonamide (4c), 4-((8-hydroxyquinolin-5-yl) diazenyl)-1, 5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one (4g)and 2-((8-hydroxyquinolin-5-yl)diazenyl) benzoic acid (4h)showed zone of inhibition at MIC level 31.25 µg mL−1against most of the organisms.The compounds4gand4hare observed with significant wound healing, analgesic and potential antioxidant activity.
