期刊名称：Beni-Suef University Journal of Basic and Applied Sciences
印刷版ISSN：2314-8535
电子版ISSN：2314-8543
出版年度：2015
卷号：4
期号：4
页码：338-345
DOI：10.1016/j.bjbas.2015.09.001
语种：English
出版社：Elsevier
摘要：AbstractA series of new 6-methoxyquinoline-3-carbonitrile derivatives were synthesized using a variety of synthetic routes. The newly synthesized compounds have been characterized by IR,1H NMR, and mass spectral data followed by elemental analysis. All of the synthesized compounds were evaluated for their in-vitro antimicrobial activity againstStreptococcus pneumoniaandBacillus subtilisas examples for Gram-positive bacteria,Pseudomonas aeruginosaandEscherichia colias examples for Gram-negative bacteria, andAspergillus fumigatus,Syncephalastrum racemosum,Geotriucum candidumandCandida albicansas representative examples of fungi. The majority of tested compounds showed moderate activities against wide range of selected organisms. Among the tested compounds, the ester derivative7band the thioether derivative9cshowed the highest antimicrobial activity against gram-positive strains while the highest activity against gram-negative strains was observed in case of7b,7dand9bwhile compound7efound more active than Amphotericin B against three fungal species.
