摘要：Amino acid-based surfactants constitute a class of cationic surfactants with excellent surface properties, wide biological activity, low potential toxicity. Essential structural factors for their antimicrobial activity include both the length of the fatty residue and the presence of the protonated guanidine function. These features and the use of natural raw materials such as Arginine and fatty acids for their synthesis, make them interesting candidates as preservatives and antiseptics in pharmaceutical, food and cosmetic formulations. The present work describes the synthesis (at lab scale), the physicochemical properties of long chain Nα-acyl arginine ethyl esters with a chain of 8 and 9 carbon atoms. These compounds have been prepared by condensation of L-arginine ethyl ester dihydrochloride with corresponding acyl chlorides in the presence of base. The basic charastristic properties such as physical appearance, structural identification by IR/H1NMR, water solubility at different pH and surface tension studies of the synthesized compounds are discussed. The Antimicrobial properties of the compounds of invention are studied by determining their Minimum inhibitory concentration for different microorganisms.
