Objectives: This study was carried out with the aim of validation of Saving Inventory-Revised (SI-R), which includes subjects related to hoarding and the failure to discard possessions that are useless or of limited value, and occur in many clinical syndromes, especially in obsessive-compulsive disorder. Method: In this descriptive cross-sectional study 348 individuals (142 males and 206 females) were randomly selected from different schools of Allameh Tabatabaie University, and were evaluated using SI-R and Padoa Obsessive-Compulsive Inventory. Data were analyzed using factor analysis through principal component analysis, step by step multivariate regression analysis, and Pearson’s correlation coefficient. Results: To obtain structure validity, principal component analysis with Promax rotation identified three factors, namely, difficulty discarding, clutter, and hoarding. These factors accounted for 70.82% of the total variance. Examination of the validity was carried out at the same time as the administration of Padoa Obsessive-Compulsive Inventory, and results of multivariate regression analysis indicated a favorable convergent validity. In addition, validity was calculated using retest, half splitting, and internal consistency coefficient. Conclusion: Considering the features of appropriate psychometrics, the aforementioned instrument can be used in researches related to a wide variety of disorders with hoarding behavior, including obsessive-compulsive disorder, obsessive-compulsive personality disorder, schizophrenia, eating disorders, impulse control disorders, and psychosomatic disorders.