Objectives: This study was conducted to examine the relationship of coping strategies and attributional styles with the risk of running away from home, among female adolescents. Method: 500 females from Meshed city (located in north east of Iran) high schools at districts 2, 5 and 7 were selected using random cluster sampling. All subjects completed 4 questionnaires: demographic characteristics, Risk of Running Away from Home, Coping Strategies, and Attributional Styles. Data were analyzed using Pearson correlation and stepwise multiple regression. Results: There was significant relationship between female’s running away from home and social support coping strategies, physical and emotional inhibition, stable-unstable aspects of failure, and stable-unstable, internal-external, and total-partial aspects of success in Attributional Styles Questionnaire. Regression analysis revealed a significant role for physical and emotional inhibition strategies and total-partial success in female’s running away from home (p<0.01). Conclusion: There was significant correlation between coping strategies and attributional styles with risk of females’ running away from home.